The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2009
Filed:
Oct. 11, 2005
Andrew Frederick Wilks, South Yarra, AU;
Christopher John Burns, Seddon, AU;
Emmanuelle Fantino, Elwood, AU;
Isabelle Lucet, Glen Waverley, AU;
Jamie Rossjohn, Carnegie, AU;
Michelle Leanne Styles, Golden Square, AU;
Andrew Frederick Wilks, South Yarra, AU;
Christopher John Burns, Seddon, AU;
Emmanuelle Fantino, Elwood, AU;
Isabelle Lucet, Glen Waverley, AU;
Jamie Rossjohn, Carnegie, AU;
Michelle Leanne Styles, Golden Square, AU;
Cytopia Research Pty Ltd, Richmond, AU;
Abstract
The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.