The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2009
Filed:
Jan. 27, 2003
Dominique Swinnen, Beaumont, FR;
Agnes Bombrun, Monnetier-Mornex, FR;
Jerome Gonzalez, Annemasse, FR;
Patrick Gerber, Villars-sous-Yens, CH;
Pierre-andre Pittet, Gilly, CH;
Dominique Swinnen, Beaumont, FR;
Agnes Bombrun, Monnetier-Mornex, FR;
Jerome Gonzalez, Annemasse, FR;
Patrick Gerber, Villars-sous-Yens, CH;
Pierre-Andre Pittet, Gilly, CH;
Laboratoires Serono SA, Coinsins, CH;
Abstract
The present invention is related to substituted methylene amide derivatives of formula (I) and use thereof for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or pyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of substituted methylene amide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs. Also the present invention relates to a method of treating diabetes type II, obesity and to regulate the appetite of mammals. The present invention is furthermore related to novel substituted methylene amide derivatives and method of preparation thereof. Formula (I).