The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 22, 2009

Filed:

Feb. 01, 2006
Applicants:

Allan R. Shepard, Fort Worth, TX (US);

Jon E. Chatterton, Crowley, TX (US);

Abbot F. Clark, Arlington, TX (US);

Martin B. Wax, Westlake, TX (US);

Inventors:

Allan R. Shepard, Fort Worth, TX (US);

Jon E. Chatterton, Crowley, TX (US);

Abbot F. Clark, Arlington, TX (US);

Martin B. Wax, Westlake, TX (US);

Assignee:

Alcon, Inc., Hunenberg, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; β1- and β2 adrenergic receptors; acetylcholinesterase; Na/K-ATPase; and Na—K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.


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