The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2009
Filed:
Apr. 19, 2004
Shailaja Kasibhatla, San Diego, CA (US);
Sui Xiong Cai, San Diego, CA (US);
Ben Tseng, San Diego, CA (US);
Katayoun Alavi Jessen, San Diego, CA (US);
Nicole Marion English, San Diego, CA (US);
Serguei Maliartchouk, San Diego, CA (US);
Songchun Jiang, San Diego, CA (US);
Nilantha Sudath Sirisoma, San Diego, CA (US);
Han-zhong Zhang, San Diego, CA (US);
Jared Kuemmerle, Del Mar, CA (US);
Shailaja Kasibhatla, San Diego, CA (US);
Sui Xiong Cai, San Diego, CA (US);
Ben Tseng, San Diego, CA (US);
Katayoun Alavi Jessen, San Diego, CA (US);
Nicole Marion English, San Diego, CA (US);
Serguei Maliartchouk, San Diego, CA (US);
Songchun Jiang, San Diego, CA (US);
Nilantha Sudath Sirisoma, San Diego, CA (US);
Han-Zhong Zhang, San Diego, CA (US);
Jared Kuemmerle, Del Mar, CA (US);
Cytovia, Inc., Tarrytown, NY (US);
Abstract
The present invention relates to screening methods useful for drug discovery of apoptosis inducing compounds. In particular, the screening methodology relates to using Apoptosis Inducing Proteins (AIPs) as a target for the discovery of apoptosis activators useful as anticancer agents. The screening methods of the present invention can employ homogenous or heterogeneous binding assays using purified or partially purified AIPs; or whole cell assays using cells with altered levels of one or more AIPs. The invention also contemplates use of gambogic acid or GA-related compounds which bind AIPs and can accordingly be used to raise antibodies useful for drug discovery. Alternatively, labeled GA is used for competitive binding assays for drug discovery. Such assays afford high throughput screening of chemical libraries for apoptosis activators.