The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2009
Filed:
Apr. 30, 2004
Kanazawa Ichiro, Tokyo, JP;
Liu Wanzhao, Tokyo, JP;
Yu-lai Wang, Tokyo, JP;
Keiji Wada, Tokyo, JP;
Jun Goto, Tokyo, JP;
Miho Murata, Tokyo, JP;
Kanazawa Ichiro, Tokyo, JP;
Liu Wanzhao, Tokyo, JP;
Yu-Lai Wang, Tokyo, JP;
Keiji Wada, Tokyo, JP;
Jun Goto, Tokyo, JP;
Miho Murata, Tokyo, JP;
Japan Science and Technology Agency, Saitama, JP;
Abstract
It is intended to provide methods for suppressing the huntington gene expression by using a double-stranded RNA (dsRNA), huntington gene expression inhibitors to suppress the huntington gene expression, and preventives and/or remedies of Huntington's disease. Targeting against a specific sequence of mRNA at immediately upstream of CAG repeats in HD genes of Huntington's disease, the huntington gene expression is suppressed by using a dsRNA homologous to the sequence. In this invention, a short siRNA (short double-stranded RNA) having bp as short as around 21-23 bp can be effectively used as the dsRNA homologous to a specific RNA sequence in a region at immediately upstream of CAG repeats. The dsRNA of this present invention can be used as a huntington gene expression inhibitor, or a preventive and/or a remedy of Huntington's disease by administering or introducing into a living body or a living cell in mammals for the prevention and/or treatment of Huntington's disease.