The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2009
Filed:
Apr. 28, 2005
Claudio Pisano, Rome, IT;
Giuseppe Giannini, Pomezia, IT;
Loredana Vesci, Pomezia, IT;
Domenico Alloatti, Pomezia, IT;
Sergio Penco, Milan, IT;
Alma Dal Pozzo, Milan, IT;
NI Ming Hong, Milan, IT;
Sabrina Dallavalle, Vimercate, IT;
Lucio Merlini, Milan, IT;
Maria Ornella Tinti, Pomezia, IT;
Franco Zunino, Milan, IT;
Claudio Pisano, Rome, IT;
Giuseppe Giannini, Pomezia, IT;
Loredana Vesci, Pomezia, IT;
Domenico Alloatti, Pomezia, IT;
Sergio Penco, Milan, IT;
Alma Dal Pozzo, Milan, IT;
Ni Ming Hong, Milan, IT;
Sabrina Dallavalle, Vimercate, IT;
Lucio Merlini, Milan, IT;
Maria Ornella Tinti, Pomezia, IT;
Franco Zunino, Milan, IT;
Abstract
Compounds of Formula (I) are described: in which the Rgroup is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αβand αβand with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.