The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2009
Filed:
Aug. 20, 2002
Cordelia Schiene-fischer, Halle, DE;
Gunter Fischer, Halle, DE;
Judith Maria Habazettl, Richen, CH;
Gerhard Küllertz, Halle, DE;
Cordelia Schiene-Fischer, Halle, DE;
Gunter Fischer, Halle, DE;
Judith Maria Habazettl, Richen, CH;
Gerhard Küllertz, Halle, DE;
Abstract
The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called 'secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. Thus, the invention relates to pharmaceutical compositions comprising substances which inhibit APIase activity.