The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2009
Filed:
Jul. 01, 2004
Dennis Heemskerk, Schinveld, NL;
Anja Gerarda Margaretha Hogenboom, Maria Hoop, NL;
Carlos Enrique Lenhardt, Alella Barcelona, ES;
Harold Monro Moody, Gulpen, NL;
Theodorus Johannes Godfried Maria Van Dooren, Roermond, NL;
Dennis Heemskerk, Schinveld, NL;
Anja Gerarda Margaretha Hogenboom, Maria Hoop, NL;
Carlos Enrique Lenhardt, Alella Barcelona, ES;
Harold Monro Moody, Gulpen, NL;
Theodorus Johannes Godfried Maria Van Dooren, Roermond, NL;
DSM IP Assets B.V., Heerlen, NL;
Abstract
The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixture to form cephradine, resulting in a conversion of 7-ADCA into cephradine of at least 70%, wherein the concentration D-dihydrophenylglycine (DH) in the reaction mixture is below 2 wt.%, wherein the conversion of 7-ADCA into cephradine & equals; (n/n)*100%, wherein n=quantity of cephradine formed (in mole); and n=total quantity of 7-ADCA added to reaction mixture (in mole). The invention also describes a process for the preparation of cephradine hydrate characterised in that the process comprises: —reacting 7-amino acid desacetoxy cephalosporanic acid (7-ADCA) with DHa in the presence of an enzyme in a reaction mixture to form cephradine; —preparing an aqueous solution comprising at least part of the cephradine; and crystallising the cephradine from said aqueous solution. The invention further describes cephradine hydrate obtainable by a process according to invention. The invention also describes cephradine hydrate with an absorbance at 450 nm of below 0.050.