The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2009
Filed:
Apr. 22, 2004
Atsushi Tendo, Saitama, JP;
Toshihiro Takahashi, Saitama, JP;
Tomio Yamakawa, Chiba, JP;
Kazuki Okai, Saitama, JP;
Susumu Nihashi, Chiba, JP;
Atsushi Tendo, Saitama, JP;
Toshihiro Takahashi, Saitama, JP;
Tomio Yamakawa, Chiba, JP;
Kazuki Okai, Saitama, JP;
Susumu Nihashi, Chiba, JP;
Nippon Chemiphar Co., Ltd., Chiyoda-ku, Tokyo, JP;
Abstract
The invention relates to purification of (2S,3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid [hereinafter, referred to as the carboxylic acid] using the salt of the carboxylic acid with an organic amine selected from the group consisting of piperazine, adamantane amines and others. The invention also relates to providing crystalline sodium salt of the carboxylic acid. The sodium salt is usable as a material for preparing medicaments and improved in storage stability, and has the following characteristics: DSC: exothermic peak observed at a temperature in the range of 170 to 175° C. with weight decrease; and characteristic absorption bands of infrared absorption spectrum (KBr tablet): 3255, 2950, 2860, 1670, 1630, 1550, 1460, 1435, 1395, 1365, 1310, 1260, 1110, 890 cm.