The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2009
Filed:
Oct. 04, 2005
Kathleen Battista, Ewing, NJ (US);
Gilles Bignan, Bridgewater, NJ (US);
Peter J. Connolly, New Providence, NJ (US);
Allen B. Reitz, Lansdale, PA (US);
Tina Morgan Ross, Royerford, PA (US);
Malcolm Scott, Telford, PA (US);
Steven A. Middleton, Flemington, NJ (US);
Michael Orsini, Somerset, NJ (US);
Kathleen Battista, Ewing, NJ (US);
Gilles Bignan, Bridgewater, NJ (US);
Peter J. Connolly, New Providence, NJ (US);
Allen B. Reitz, Lansdale, PA (US);
Tina Morgan Ross, Royerford, PA (US);
Malcolm Scott, Telford, PA (US);
Steven A. Middleton, Flemington, NJ (US);
Michael Orsini, Somerset, NJ (US);
Janssen Pharmaceutica, NV, Beerse, BE;
Abstract
The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.