The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2009
Filed:
Mar. 01, 2006
Francisco Borras Cuesta, Pamplona, ES;
Javier Dotor DE Las Herrerias, Pamplona, ES;
Juan Manuel Irache Garreta, Pamplona, ES;
Fernando Martinez Galan, Pamplona, ES;
Jesus Prieto Valtuena, Pamplona, ES;
Francisco Borras Cuesta, Pamplona, ES;
Javier Dotor De Las Herrerias, Pamplona, ES;
Juan Manuel Irache Garreta, Pamplona, ES;
Fernando Martinez Galan, Pamplona, ES;
Jesus Prieto Valtuena, Pamplona, ES;
Digna Biotech, S.L., Navarra, ES;
Abstract
A Method for the treatment of skin fibrosis with a peptide that inhibits TGF-β, and suitable compositions for its administration. The method includes in particular, the use of peptide P144, a compound that is a known inhibitor of TGF-β, for the treatment of skin fibrosis by topical application. The method is shown effective in an animal model of bleomycin-induced skin sclerosis, to a reduction both of the skin fibrosis and of the content of soluble collagen, without any signs of systemic toxicity being detected. This shows that P144 is effective for topical application in mammals for treating fibrotic skin diseases and pathological scarring of the skin. For the administration of this peptide, stable compositions are also supplied, with pleasant appearance without being greasy, with good spreading characteristics and with a viscosity that permits it to be processed easily in industrial plant, and which are suitable for administering the peptide to humans.