The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2009
Filed:
Feb. 18, 2005
Jan Wim Vrijbloed, Zurich, CH;
Daniel Obrecht, Battwil, CH;
John Anthony Robinson, Wermatswil, CH;
Odile Sellier, Sausheim, FR;
Marc Kessler, Bischheim, FR;
Jan Wim Vrijbloed, Zurich, CH;
Daniel Obrecht, Battwil, CH;
John Anthony Robinson, Wermatswil, CH;
Odile Sellier, Sausheim, FR;
Marc Kessler, Bischheim, FR;
Polyphor Ltd., Allschwil, CH;
Universität Zürich, Zürich, CH;
Abstract
Template-fixed β-hairpin peptidomimetics of the general formula (I), wherein Z is a template-fixed chain of 12 α-amino acid residues which, depend on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such asand. They can be used as disinfectants for foodstuff, cosmetics, medicaments or other nutrient-containing materials, or as medicaments or treat or prevent infections. In a specific embodiment, the template is based on the D-Pro-L-Pro dipeptide. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.