The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2009
Filed:
Jan. 22, 2004
Applicants:
Robert J. Schwartz, Houston, TX (US);
Lei Wei, Pearland, TX (US);
Jiang Chang, Houston, TX (US);
Mark Entman, Houston, TX (US);
Inventors:
Robert J. Schwartz, Houston, TX (US);
Lei Wei, Pearland, TX (US);
Jiang Chang, Houston, TX (US);
Mark Entman, Houston, TX (US);
Assignee:
Baylor College of Medicine, Houston, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 48/00 (2006.01); A61K 38/30 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising elevated cleavage of serum response factor. In further specific embodiments, heart failure is associated with cardiac myocyte apoptosis as a result of an increase in cleaved serum response factor, particularly by caspases.