The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2009
Filed:
Mar. 01, 2006
Nigel Ian Bowers, Yardley, PA (US);
Paul M. Skonezny, Baldwinsville, NY (US);
Gregory L. Stein, Mallory, NY (US);
Thomas Franceschini, Cicero, NY (US);
Shu-jen Chiang, Manlius, NY (US);
Wendy L. Anderson, Mexico, NY (US);
LI You, Jamesville, NY (US);
Zizhuo Xing, Syracuse, NY (US);
Nigel Ian Bowers, Yardley, PA (US);
Paul M. Skonezny, Baldwinsville, NY (US);
Gregory L. Stein, Mallory, NY (US);
Thomas Franceschini, Cicero, NY (US);
Shu-Jen Chiang, Manlius, NY (US);
Wendy L. Anderson, Mexico, NY (US);
Li You, Jamesville, NY (US);
Zizhuo Xing, Syracuse, NY (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenizedhaving ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenizedhaving ATCC deposit no. PTA-6648.