The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2009
Filed:
Sep. 20, 2004
Michele Sanicola-nadel, Winchester, MA (US);
Heather Adkins, Somerville, MA (US);
Steven Donald Miklasz, Upton, MA (US);
Paul Rayhorn, Foxboro, MA (US);
Susan Gail Schiffer, Lexington, MA (US);
Kevin P. Williams, Chapel Hill, NC (US);
Michele Sanicola-Nadel, Winchester, MA (US);
Heather Adkins, Somerville, MA (US);
Steven Donald Miklasz, Upton, MA (US);
Paul Rayhorn, Foxboro, MA (US);
Susan Gail Schiffer, Lexington, MA (US);
Kevin P. Williams, Chapel Hill, NC (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Abstract
The invention provides Cripto-specific antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and inhibit Cripto activity are provided. Antibodies which bind Cripto and inhibit the interaction between Cripto and ALK4 and/or between Cripto and Activin B are provided. Antibodies which bind Cripto and inhibit tumor growth are also provided. Antibodies which bind Cripto, inhibit Cripto activity, and inhibit tumor growth are also provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.