The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2009
Filed:
Oct. 10, 2006
Sunil Kumar Chattopadhyay, Uttar Pradesh, IN;
Sachin Srivastava, Uttar Pradesh, IN;
Arvind Singh Negi, Uttar Pradesh, IN;
Ranganathan Santha Kumar Tirupadiripuliyur, Pradesh, IN;
Ankur Garg, Uttar Pradesh, IN;
Suman Preet Singh Khanuja, Uttar Pradesh, IN;
Sunil Kumar Chattopadhyay, Uttar Pradesh, IN;
Sachin Srivastava, Uttar Pradesh, IN;
Arvind Singh Negi, Uttar Pradesh, IN;
Ranganathan Santha Kumar Tirupadiripuliyur, Pradesh, IN;
Ankur Garg, Uttar Pradesh, IN;
Suman Preet Singh Khanuja, Uttar Pradesh, IN;
Council of Scientific and Industrial Research, New Delhi, IN;
Abstract
The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genusby first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.