The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2009
Filed:
Apr. 28, 2008
Fabienne Hoffmann-emery, Weil am Rhein, DE;
Roland Jakob-roetne, Inzlingen, DE;
Fabienne Hoffmann-Emery, Weil am Rhein, DE;
Roland Jakob-Roetne, Inzlingen, DE;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The invention relates to a process for the optical resolution of a dibenzo[b,d]azepinone derivative of formula II, wherein Ris hydrogen or halogen and Ris either C-alkyl optionally substituted with C-cycloalkyl or benzyl which is optionally substituted with C-alkoxy, to obtain a (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one of formula I, wherein Ris as in the compound of formula II. The (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one of formula I can be used as a chiral building block for the preparation of malonamide derivatives which have the potential to act as γ-secretase inhibitors and therefore may be useful in the treatment of Alzheimer's disease and cancer.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile