The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2009
Filed:
Aug. 27, 2008
Julian Adams, Boston, MA (US);
Yun Gao, Southborough, MA (US);
Asimina T. Georges Evangelinos, Chestnut Hill, MA (US);
Louis Grenier, Newton, MA (US);
Roger H. Pak, Boxborough, MA (US);
James R. Porter, Rowley, MA (US);
James L. Wright, Lexington, MA (US);
Julian Adams, Boston, MA (US);
Yun Gao, Southborough, MA (US);
Asimina T. Georges Evangelinos, Chestnut Hill, MA (US);
Louis Grenier, Newton, MA (US);
Roger H. Pak, Boxborough, MA (US);
James R. Porter, Rowley, MA (US);
James L. Wright, Lexington, MA (US);
Infinity Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.