The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2009
Filed:
Dec. 24, 2003
Goutam Gupta, Santa Fe, NM (US);
Elizabeth Hong-geller, Los Alamos, NM (US);
Patrick R. Shiflett, Los Alamos, NM (US);
Nancy M. Lehnert, Albuquerque, NM (US);
Goutam Gupta, Santa Fe, NM (US);
Elizabeth Hong-Geller, Los Alamos, NM (US);
Patrick R. Shiflett, Los Alamos, NM (US);
Nancy M. Lehnert, Albuquerque, NM (US);
Los Alamos National Security, LLC, Los Alamos, NM (US);
Abstract
The invention provides therapeutic compositions useful in the treatment of bacterial superantigen mediated conditions, such as Toxic Shock Syndrome. The compositions comprise genetically engineered bifunctional polypeptides containing a specific T-cell receptor binding domain and a specific MHC class II receptor binding domain, each targeting non-overlapping epitopes on a superantigen molecule against which they are designed. The anti-superantigen 'receptor mimetics' or 'chimeras' are rationally designed to recreate the modality of superantigen binding directly to both the TCR and the MHC-II receptor, and are capable of acting as decoys for superantigen binding, effectively out-competing the host T-cell and MHC-II receptors, the natural host receptors.