The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2009
Filed:
Sep. 08, 2004
James Norris, Mt. Pleasant, SC (US);
Gary Clawson, Bethesda, MD (US);
Caroline Westwater, Mt. Pleasant, SC (US);
David Schofield, Mt. Pleasant, SC (US);
Michael G. Schmidt, Charleston, SC (US);
Brian Hoel, Charleston, SC (US);
Joseph Dolan, Mt. Pleasant, SC (US);
Wei-hua Pan, Hummelstown, PA (US);
James Norris, Mt. Pleasant, SC (US);
Gary Clawson, Bethesda, MD (US);
Caroline Westwater, Mt. Pleasant, SC (US);
David Schofield, Mt. Pleasant, SC (US);
Michael G. Schmidt, Charleston, SC (US);
Brian Hoel, Charleston, SC (US);
Joseph Dolan, Mt. Pleasant, SC (US);
Wei-Hua Pan, Hummelstown, PA (US);
The Penn State Research Foundation, University Park, PA (US);
Abstract
The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).