The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 18, 2009

Filed:

Apr. 27, 2005
Applicants:

Wylie Vale, La Jolla, CA (US);

Craig Harrison, Nunawading, AU;

Peter Gray, Encinitas, CA (US);

Wolfgang Fischer, Encinitas, CA (US);

Senyon Choe, Solana Beach, CA (US);

Inventors:

Wylie Vale, La Jolla, CA (US);

Craig Harrison, Nunawading, AU;

Peter Gray, Encinitas, CA (US);

Wolfgang Fischer, Encinitas, CA (US);

Senyon Choe, Solana Beach, CA (US);

Assignee:

Research Development Foundation, Carson City, NV (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Members of the TGF-β superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-β ligands including activins, myostatin, BMPs and nodal. Methods are described for the screening and identification of antagonist for TGF-β superfamily members, in particular activin-A antagonist.


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