The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2009
Filed:
Aug. 26, 2005
Robert W. Brueggemeier, Dublin, OH (US);
Young-woo Kim, Columbus, OH (US);
John C. Hackett, Dublin, OH (US);
Robert W. Brueggemeier, Dublin, OH (US);
Young-Woo Kim, Columbus, OH (US);
John C. Hackett, Dublin, OH (US);
The Ohio State University Research Foundation, Columbus, OH (US);
Abstract
Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: wherein X is selected from O, N, S, SO, SO, and S(CH), wherein n=1-10; Rand Rmay be the same or different and are selected from H, OH, OCH, OCHCH, OCHCH, NH, NHCH, N(CH), CH, CHCH, CHCHCH, CH(CH), C(CH), NO, F, Cl, Br, CF, SH, SCH, SCHCH, OCOCH, OCOC(CH), OCOCHCOOH, and CN; and Ris a nitrogen-containing heterocyclic ring. Also provided are method for treating or preventing cancer in a subject by administering a therapeutically effective amount of a heteroaryl-containing isoflavone, or a pharmaceutically acceptable salt or prodrug thereof, to a subject in need of treatment. Also provided is a method for the synthesis of 2-substituted isoflavones by first reacting deoxybenzoins with a phase transfer catalyst to provide a 2-(alkylthio)isoflavone; second deprotecting the 2-(alkylthio)isoflavone; and third applying selective debenzylation to form the final compound.