The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2009
Filed:
Jul. 14, 2004
Guang-pei Chen, Livingston, NJ (US);
Prasad K Kapa, Parsippany, NJ (US);
Eric M Loeser, Lake Hiawatha, NJ (US);
Ulrich Beutler, Oberwil, CH;
Werner Zaugg, Riehen, CH;
Michael J Girgis, Montville, NJ (US);
Guang-Pei Chen, Livingston, NJ (US);
Prasad K Kapa, Parsippany, NJ (US);
Eric M Loeser, Lake Hiawatha, NJ (US);
Ulrich Beutler, Oberwil, CH;
Werner Zaugg, Riehen, CH;
Michael J Girgis, Montville, NJ (US);
Novartis AG, Basel, CH;
Abstract
A method for preparing an alkali metal salt comprising: (a) condensing a disilyloxydiene with an aldehyde in the presence of a titanium (IV) catalyst in an inert solvent to form a 5(S)-hydroxy-3-ketoester; (b) reducing the 5(S)-hydroxy-3-ketoester to a 3(R),5(S)-dihydroxyester in the presence of a di(lower alkyl)methoxyborane; and (c) hydrolyzing the 3(R),5(S)-dihydroxyester in the presence of an aqueous base to form an alkali metal salt.