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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7572816 B1

PDFFull Text
Expired
Date of Patent:
Aug. 11, 2009

Filed:

Jul. 21, 2004

Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders

Applicants:

Bruno Tse, San Diego, CA (US);

Sepehr Sarshar, Cardiff by the Sea, CA (US);

Inventors:

Bruno Tse, San Diego, CA (US);

Sepehr Sarshar, Cardiff by the Sea, CA (US);

Assignee:

Auspex Pharmaceuticals, Inc., Vista, CA (US);

Attorneys:

Dennis A. Bennett

Michael Sertic

Primary Examiner:

Kamal A Saeed

Assistant Examiner:

Samantha L Shterengarts

Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/425 (2006.01); A61K 31/415 (2006.01); C07D 295/00 (2006.01); C07D 207/00 (2006.01); C07D 401/00 (2006.01); C07D 233/00 (2006.01); C07D 277/00 (2006.01); C07D 409/00 (2006.01); C07D 403/00 (2006.01); C07D 239/02 (2006.01); C07D 215/02 (2006.01); C07D 271/00 (2006.01); C07D 285/02 (2006.01); C07D 257/04 (2006.01); C07D 487/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is directed to compounds having the structure wherein R, R, R, R, Rand m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals

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