The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2009
Filed:
Jul. 06, 2004
Giuseppe Giannini, Pomezia, IT;
Domenico Alloatti, Rome, IT;
Marcella Marcellini, Rome, IT;
Mauro Marzi, Rome, IT;
Teresa Riccioni, Rome, IT;
Maria Ornella Tinti, Rome, IT;
Giuseppe Giannini, Pomezia, IT;
Domenico Alloatti, Rome, IT;
Marcella Marcellini, Rome, IT;
Mauro Marzi, Rome, IT;
Teresa Riccioni, Rome, IT;
Maria Ornella Tinti, Rome, IT;
Abstract
The present invention is related to new derivatives of Combretastatin, of Formula obtained by total synthesis. The strategy developed for each of the compounds is to i) replace a halogen (i.e. fluorine atom) to hydrogen on olefinic bound; ii) replace an aromatic ring in a natural product with an amino-aromatic ring. Said compounds recognize and bind the tubulin site: are useful for treating pathological states which arise from or are exacerbated by cell proliferation—as anticancer and/or antiangiogenic activity, in a mammal—to pharmaceutical compositions comprising these compounds.