The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2009
Filed:
Feb. 24, 2004
Wolfgang Skranc, Vienna, AT;
Anton Glieder, Gleisdorf, AT;
Karl Gruber, Graz, AT;
Roland Weis, Graz, AT;
Ruud Luiten, Leiden, NL;
Wolfgang Skranc, Vienna, AT;
Anton Glieder, Gleisdorf, AT;
Karl Gruber, Graz, AT;
Roland Weis, Graz, AT;
Ruud Luiten, Leiden, NL;
DSM Fine Chemicals Austria NFG GmbH & Co. KG, Linz, AT;
Abstract
The invention relates to R-hydroxynitrillyases from the family of Rosaceae that are characterized by an improved substrate tolerance and increased stability. In the active center of the R-hydroxynitrillyases either a) an alanine group is substituted by glycine, valine, leucine, isoleucine, or phenylalanine or b) a phenylalanine group is substituted by alanine, glycine valine, leucine or isoleucine, or c) a leucine group is substituted by alanine, glycine, valine, isoleucine or phenylalanine, or d) an isoleucine group is substituted by alanine, glycine, valine, leucine or phenylalanine. The invention also relates to the use of these lyases in the production of enantiomer-pure R- or S-cyanohydrines.