The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2009

Filed:

Aug. 04, 2003
Applicants:

Roland Maier, Biberach, DE;

Frank Himmelsbach, Mittelbiberach, DE;

Matthias Eckhardt, Biberach, DE;

Elke Langkopf, Warthausen, DE;

Michael Mark, Biberach, DE;

Ralf R. H. Lotz, Schemmerhofen, DE;

Inventors:

Roland Maier, Biberach, DE;

Frank Himmelsbach, Mittelbiberach, DE;

Matthias Eckhardt, Biberach, DE;

Elke Langkopf, Warthausen, DE;

Michael Mark, Biberach, DE;

Ralf R. H. Lotz, Schemmerhofen, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 473/30 (2006.01); C07D 473/18 (2006.01); C07D 473/04 (2006.01); C07D 473/06 (2006.01); A61K 31/522 (2006.01); A61P 3/10 (2006.01); A61P 3/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to new purine derivatives of general formula wherein Rto Rare defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV), the preparation thereof, the use thereof for the prevention or treatment of diseases or conditions associated with an increased DPP-IV activity or capable of being prevented or alleviated by reducing the DPP-IV activity, particularly type I or type II diabetes mellitus, the pharmaceutical compositions containing a compound of general formula (I) or a physiologically acceptable salt thereof as well as processes for the preparation thereof.


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