The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2009
Filed:
Feb. 13, 2007
Lisset Hermida Cruz, Ciudad de La Habana, CU;
Rayner Rodriguez Diaz, Ciudad de La Habana, CU;
Laura Lazo Vazquez, Ciudad de La Habana, CU;
Aida Zulueta Morales, Ciudad de La Habana, CU;
Carlos Lopez Abarrategui, Ciudad de La Habana, CU;
Iris Valdes Prado, Ciudad de La Habana, CU;
Ricardo DE LA C. Silva Rodriguez, Ciudad de La Habana, CU;
Glay Chinea Santiago, Ciudad de La Habana, CU;
Gerardo Enrique Guillen Nieto, Ciudad de La Habana, CU;
Maria Guadalupe Guzman Tirado, Ciudad de La Habana, CU;
Beatriz DE LA Caridad Sierra Vazquez, Ciudad de La Habana, CU;
Raul Rafael Espinosa Perez, Ciudad de La Habana, CU;
Lisset Hermida Cruz, Ciudad de La Habana, CU;
Rayner Rodriguez Diaz, Ciudad de La Habana, CU;
Laura Lazo Vazquez, Ciudad de La Habana, CU;
Aida Zulueta Morales, Ciudad de La Habana, CU;
Carlos Lopez Abarrategui, Ciudad de La Habana, CU;
Iris Valdes Prado, Ciudad de La Habana, CU;
Ricardo de la C. Silva Rodriguez, Ciudad de La Habana, CU;
Glay Chinea Santiago, Ciudad de La Habana, CU;
Gerardo Enrique Guillen Nieto, Ciudad de La Habana, CU;
Maria Guadalupe Guzman Tirado, Ciudad de La Habana, CU;
Beatriz de la Caridad Sierra Vazquez, Ciudad de La Habana, CU;
Raul Rafael Espinosa Perez, Ciudad de La Habana, CU;
Centro de Ingeniera Genetica y Biotecnologia, Ciudad de La Habana, CU;
Abstract
The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonspecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein fromwith dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.