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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7563595 B1

PDFFull Text
Date of Patent:
Jul. 21, 2009

Filed:

Nov. 07, 2003

Nucleic acids encoding functional splice variants of the α7 nicotinic acetylcholine receptor subunit and methods for producing the encoded proteins

Applicants:

Javier Cuevas, Lutz, FL (US);

Emily Severance, Lutz, FL (US);

Inventors:

Javier Cuevas, Lutz, FL (US);

Emily Severance, Lutz, FL (US);

Assignee:

University of South Florida, Tampa, FL (US);

Attorney:

Saliwanchik, Lloyd & Saliwanchik

Primary Examiner:

Daniel E Kolker

Int. Cl.
CPC ...
C12P 21/02 (2006.01); C12N 1/21 (2006.01); C12N 15/12 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention concerns a novel α7 nicotinic receptor subunit isoform, α7-2. The α7-2 isoform contributes to novel acetylcholine receptors (AChRs) with pharmacological and biophysical properties distinct from those of wild-type α7-1-nAChRs and closely resembling those of α7-nAChRs found in intrinsic cardiac neurons and Type II α7-nAChRs of superior cervical ganglion neurons. Polynucleotides encoding the α7-2 isoform, vectors and genetically modified cells containing such polynucleotides are also provided. In addition, methods are provided for producing the α7-2 isoform as are methods of using such isoforms for screening compounds for activity at the nAChR.

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