The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2009
Filed:
Oct. 24, 2007
Hans J. Hansen, Picayune, MS (US);
Gary L. Griffiths, Morristown, NJ (US);
Shui-on Leung, Hong Kong, HK;
William J. Mcbride, Boonton, NJ (US);
Zhengxing Qu, Warren, NJ (US);
Hans J. Hansen, Picayune, MS (US);
Gary L. Griffiths, Morristown, NJ (US);
Shui-on Leung, Hong Kong, HK;
William J. McBride, Boonton, NJ (US);
Zhengxing Qu, Warren, NJ (US);
Immunomedics, Inc., Morris Plains, NJ (US);
Abstract
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. In preferred embodiments, the hapten is histamine-succinyl-glycine (HSG). In more preferred embodiments, the at least one arm comprises the CDR sequences of the HSG-binding 679 antibody. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. In one embodiment, the invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them.