The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2009
Filed:
Aug. 22, 2003
Kiyoshi Shimizu, Takasaki, JP;
Toshiyuki Shimizu, Takasaki, JP;
Kaname Kimura, Takasaki, JP;
Kazuki Kawakami, Takasaki, JP;
Masayoshi Nakoji, Takasaki, JP;
Kiyoshi Shimizu, Takasaki, JP;
Toshiyuki Shimizu, Takasaki, JP;
Kaname Kimura, Takasaki, JP;
Kazuki Kawakami, Takasaki, JP;
Masayoshi Nakoji, Takasaki, JP;
Kirin Beer Kabushiki Kaisha, Tokyo-to, JP;
Abstract
The present invention provides compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein X represents CH or N; Z represents —O—, —NH— or —C(═O)—; R and R' represent a hydrogen atom, hydroxyl, a halogen atom, optionally substituted alkyl, optionally substituted alkenyl optionally substituted alkoxy, amino, aminocarbonyl, or an optionally substituted heterocyclic group; and A represents an optionally substituted specific carbocyclic or heterocyclic group. The compounds according to the present invention have excellent TGFβ inhibitory activity.