The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2009
Filed:
Dec. 16, 2003
Jonathan Mark Hardy, Mt Pleasant, TN (US);
Stephen Edward Dinizo, Mt Pleasant, TN (US);
Jonathan Mark Hardy, Mt Pleasant, TN (US);
Stephen Edward Dinizo, Mt Pleasant, TN (US);
Avecia Biotechnology Inc., Milford, MA (US);
Abstract
A process for the preparation of a compound of formula R—Y—P(NRR)is provided. The process comprises reacting a compound of formula PXwith a compound of formula HNRRto form a compound of formula X—P(NRR); and reacting the compound of formula X—P(NRR)with a compound of formula R—Y—H in the presence of a hydrocarbon solvent to form the compound of formula R—Y—P(NRR). Rrepresents a phosphorus protecting group; Rand Reach independently represent an alkyl, prefer-ably a Calkyl, group, or Rand Rare joined, together with the N to which they are attached, to form a 5-7 membered ring; Yrepresents O or S, preferably O; and X represents a halogen, preferably Cl. The preferred solvent is toluene.