The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2009
Filed:
Jul. 09, 2003
Breda Rode, Kamnik, SI;
Damjana Rozman, Ljubljana, SI;
Klementina Fon Tacer, Ljubljana, SI;
Darko Kocjan, Ljubljana, SI;
Breda Rode, Kamnik, SI;
Damjana Rozman, Ljubljana, SI;
Klementina Fon Tacer, Ljubljana, SI;
Darko Kocjan, Ljubljana, SI;
Lek Pharmaceuticals d.d., Ljubljana, SI;
Abstract
The novel derivatives of pyridilethanol (phenylethyl) amines of formula I are described wherein n is an integer from 1 to 4, Ris a hydrogen atom, hydroxyl group or lower Calkoxy group Ris a hydrogen atom or a straight or branched lower Calkyl group X, is hydrogen, fluorine, chlorine, bromine, hydroxyl group, trifluoromethyl group, 3,4-di-Cl,2,4-di-Cl or lower Calkoxy group, the enantiomers, diastereoisomers or racemates thereof or the physiologically acceptable acid addition salts thereof which are ligands of sigma receptors for inhibiting cholesterol biosynthesis and are thus appropriate for the treatment of hypercholesterolemia and hyperlipemia in humans. The greatest lowering of cholesterol was observed by 1-(d-pyridyl)-2-(N-(2-(3,4-dicholorophenyl)ethyl-N-propylamino)ethanol in the form of dihydrobromide salt (signature BK-35, 2HBr).