The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2009
Filed:
Dec. 18, 2003
Richard Carter, Newark, DE (US);
Martin Rosenburg, Madison, WI (US);
Daniel R. Gentry, Pottstown, PA (US);
Nigel Grinter, Buffalo Grove, IL (US);
Richard Carter, Newark, DE (US);
Martin Rosenburg, Madison, WI (US);
Daniel R. Gentry, Pottstown, PA (US);
Nigel Grinter, Buffalo Grove, IL (US);
Promega Corporation, Madison, WI (US);
Abstract
Methods for specific RNA capture, detection and quantification are presented utilizing a protein that selectively binds RNA:DNA hybrids, preferably an RNase H that is modified to reduce degradation of the nucleic acid molecules and enhance specific detection of mixed RNA:DNA nucleic acid hybrids. Labeling of the RNA and/or amplification is not required to perform these methods. Modified RNase H enzymes useful in such methods are disclosed.