The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2009
Filed:
Dec. 22, 2004
Laurence Hylton Patterson, West Yorkshire, GB;
Klaus Pors, West Yorkshire, GB;
Paul Henry Teesdale-spittle, Wellington, NZ;
Laurence Hylton Patterson, West Yorkshire, GB;
Klaus Pors, West Yorkshire, GB;
Paul Henry Teesdale-Spittle, Wellington, NZ;
Somanta Limited, London, GB;
Abstract
Anthraquinone compounds of the general formula (I) or a salt thereof (Formula I) in which Rto Rare each selected from the group consisting of H, Calkyl, X, —NHRN (R)in which Ris a Calkanediyl and each Ris H or optionally substituted Calkyl, and a group of formula (II) in which at least one of R, Rand Ris selected from X, and Xsubstituted Calkyl and any others are H or Calkyl; Ris selected from H, Calkyl, Xand Xsubstituted Calkyl; m is 0 or 1; n is 1 or 2; Xis a halogen atom, a hydroxyl group, a Calkoxyl group, an aryloxy group or an acyloxy group; and Xis a halogen atom, a hydroxyl group, a Calkoxyl group, an aryloxy group or an acyloxy group; provided that at least one of Rto Ris a group of formula (II). The N-oxides are useful prodrugs which are selectively bioreduced in hypoxic tumours to the corresponding cyclic amine derivatives. The amine compounds are cytotoxic and may be used as alkylating agents having topoisomerase II inhibiting activities in cancer therapy.