The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2009
Filed:
Oct. 03, 2006
Donald W. Kufe, Wellesley, MA (US);
Rima Kaddurah-daouk, Belmont, MA (US);
Ralph R. Weichselbaum, Chicago, IL (US);
Donald W. Kufe, Wellesley, MA (US);
Rima Kaddurah-Daouk, Belmont, MA (US);
Ralph R. Weichselbaum, Chicago, IL (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
The University of Chicago, Chicago, IL (US);
Abstract
The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such compounds can be useful to modulate the level of apoptosis in a cell. For example, compounds identified according to the methods described herein can be used to treat disorders characterized by excessive apoptosis, e.g., a neurological disorder, or insufficient apoptosis, e.g., cancer.