The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2009
Filed:
Aug. 13, 2004
Diana Jespersen, Malvern, PA (US);
Yevgenya Akselband, Brighton, MA (US);
Patricia Mcgrath, Cambridge, MA (US);
Jan Trnovsky, Saugus, MA (US);
Phillip T. Moen, Foxborough, MA (US);
Diana Jespersen, Malvern, PA (US);
Yevgenya Akselband, Brighton, MA (US);
Patricia McGrath, Cambridge, MA (US);
Jan Trnovsky, Saugus, MA (US);
Phillip T. Moen, Foxborough, MA (US);
One Cell Systems, Inc., Cambridge, MA (US);
Abstract
The invention provides methods of analyzing a secreted protein from a cell encapsulated in a microdrop. The microdrop is formulated with biotinylated matrix molecules at a reduced ratio of biotin to matrix molecules compared with previous formulations. The reduced ratio is advantageous for improving the resolution of detection and allows simultaneous detection of multiple secreted proteins and/or multiple cell surface markers. The invention further provides inter alia methods of isolating IgG isotype antibodies that have switched from IgM isotype.