The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2009
Filed:
Apr. 04, 2002
Shohei Koide, Chicago, IL (US);
Stephen Dewhurst, Rochester, NY (US);
Akiko Koide, Chicago, IL (US);
Julie Richards, Rochester, NY (US);
Michelle Miller, Rochester, NY (US);
Shohei Koide, Chicago, IL (US);
Stephen Dewhurst, Rochester, NY (US);
Akiko Koide, Chicago, IL (US);
Julie Richards, Rochester, NY (US);
Michelle Miller, Rochester, NY (US);
University of Rochester, Rochester, NY (US);
Abstract
The present invention relates to a polypeptide monobody which includes a modified acid sequence and renders the polypeptide monobody able to bind selectively to ανβ3 integrin. Fusion proteins and conjugates which include the polypeptide monobody, as well as compositions containing the polypeptide monobody, fusion proteins, or conjugates are also disclosed. Uses thereof include: treating or preventing an ανβ3 integrin-mediated disease or disorder, inhibiting ανβ3 integrin activity, treating a cancerous or precancerous condition, imaging tissues using positron emission tomography or magnetic resonance imaging, assessing the metastatic characteristics of a tumor, and delivering DNA to a cell.