The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2009
Filed:
Apr. 05, 2006
Murray Robinson, Boston, MA (US);
Ronan O'hagan, Brookline, MA (US);
Karuppiah Kannan, Cambridge, MA (US);
Ti Cai, Andover, MA (US);
Maria Isabel Chiu, Newton Centre, MA (US);
Lorena Lerner, Newton Centre, MA (US);
Jie Lin, West Roxbury, MA (US);
Yinghui Zhou, Belmont, MA (US);
Murray Robinson, Boston, MA (US);
Ronan O'Hagan, Brookline, MA (US);
Karuppiah Kannan, Cambridge, MA (US);
Ti Cai, Andover, MA (US);
Maria Isabel Chiu, Newton Centre, MA (US);
Lorena Lerner, Newton Centre, MA (US);
Jie Lin, West Roxbury, MA (US);
Yinghui Zhou, Belmont, MA (US);
AVEO Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
A method of producing a tumorigenic mouse cell, the tumorigenicity of which depends on a recombinant gene of interest is disclosed. The method involves: (a) providing a conditionally tumorigenic mouse cell containing a recombinant oncogene operably linked to an inducible promoter, wherein (i) expression of the recombinant oncogene is necessary and sufficient for the tumorigenicity of the tumorigenic mouse cell, and (ii) the inducible promoter is in the uninduced state; and (b) introducing into the cell a recombinant gene of interest that functionally complements the oncogene, thereby restoring tumorigenicity without expression of the inducible recombinant oncogene. Also disclosed is a method of testing a compound for anti-tumor effects. The method includes producing tumorigenic mouse cells the tumorigenicity depends on expression of a recombinant gene of interest, implanting the cells in mice and obtaining tumors from the implanted cells, administering test compounds to the mice, and determining anti-tumor effects, if any, of the compounds.