The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2009
Filed:
Oct. 22, 2002
Hans-ulrich Petereit, Darmstadt, DE;
Christian Meier, Darmstadt, DE;
Klaus Schultes, Wiesbaden, DE;
Marie-andree Yessine, Montreal, CA;
Jean-christophe Leroux, Montreal, CA;
Hans-Ulrich Petereit, Darmstadt, DE;
Christian Meier, Darmstadt, DE;
Klaus Schultes, Wiesbaden, DE;
Marie-Andree Yessine, Montreal, CA;
Jean-Christophe Leroux, Montreal, CA;
Roehm GmbH & Co. KG, Darmstadt, DE;
Universite de Montreal, Montreal, CA;
Abstract
The invention relates to a pH-sensitive polymer which is a (meth)acrylate copolymer composed of 20 to 65% by weight acrylic and/or methacrylic acid units and 80 to 35% by weight units of C- to C-alkyl esters of (meth)acrylic acid, characterized in that it has a molecular weight in the range from 1 000 to 50 000 g/mol, and brings about at least 60% haemolysis at pH 5.5, and less than 5% haemolysis at pH 7.4, in a concentration of 150 μg/ml in a cytotoxicity test with human red blood cells. The invention further relates to the use of the pH-sensitive polymer as carrier for pharmaceutically effective biomolecules or active pharmaceutical ingredients and as ingredient of corresponding dosage forms.