The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2009
Filed:
Jan. 24, 2006
Applicant:
Henry Paulus, Boston, MA (US);
Inventor:
Henry Paulus, Boston, MA (US);
Assignee:
Boston Biomedical Research Institute, Watertown, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/33 (2006.01); C07K 2/00 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins. Additionally, the present invention relates to the use of the inhibitors of protein splicing of the invention for the treatment of various diseases including but not limited to tuberculosis. Furthermore, the invention provides the first instance of small molecule inhibitors of protein splicing with drug-like characteristics.