The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2009
Filed:
Oct. 30, 2007
Nozer M. Mehta, Randolph, NJ (US);
Angelo P. Consalvo, Monroe, NY (US);
Martha V. L. Ray, Nutley, NJ (US);
Christopher P. Meenan, Lincoln Park, NJ (US);
Nozer M. Mehta, Randolph, NJ (US);
Angelo P. Consalvo, Monroe, NY (US);
Martha V. L. Ray, Nutley, NJ (US);
Christopher P. Meenan, Lincoln Park, NJ (US);
Unigene Laboratories Inc., Boonton, NJ (US);
Abstract
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special universal cloning vectors are provided for the preparation of expression vectors which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.