The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2009
Filed:
Aug. 10, 2006
Torben Lauesgaard Nissen, London, GB;
Kim Vilbour Andersen, Broenshoej, DK;
Christian Karsten Hansen, Vedbaek, DK;
Jan Moller Mikkelsen, Gentofte, DK;
Hans Thalsgaard Schambye, Frederiksberg, DK;
Torben Lauesgaard Nissen, London, GB;
Kim Vilbour Andersen, Broenshoej, DK;
Christian Karsten Hansen, Vedbaek, DK;
Jan Moller Mikkelsen, Gentofte, DK;
Hans Thalsgaard Schambye, Frederiksberg, DK;
Maxygen Holdings Ltd., Grand Cayman, KY;
Abstract
Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugated recombinant human G-CSF.