The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2009
Filed:
Oct. 26, 2004
Ashok Kumar, Maharashtra, IN;
Dharmendra Singh, Maharashtra, IN;
Atul Jadhav, Maharashtra, IN;
Navinchandra Darpan Pandya, Maharashtra, IN;
Shankar Deepak Panmand, Maharashtra, IN;
Ramsingh Gajendrasingh Thakur, Maharashtra, IN;
Ashok Kumar, Maharashtra, IN;
Dharmendra Singh, Maharashtra, IN;
Atul Jadhav, Maharashtra, IN;
Navinchandra Darpan Pandya, Maharashtra, IN;
Shankar Deepak Panmand, Maharashtra, IN;
Ramsingh Gajendrasingh Thakur, Maharashtra, IN;
IPCA Laboratories Ltd., Mumbai, IN;
Abstract
A one-pot industrial process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazole-1-yl)methyl]-4H-carbazol-4-one of Formula-(I) from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one of Formula-(IV) involves reaction of Formula (IV) with HNRRsalt and paraformaldehyde, where R,Rare independently alkyl groups or together forms a cyclic alkyl group, in a solvent system of acetic acid and hydrocarbon solvent to form a crude mixture of intermediate compounds of Formula (III) and (VIII), which is converted to ondansetron (Formula (I)) without isolation by reaction with 2methyimidazole in a suitable solvent system in the same pot.