The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2009
Filed:
Jun. 23, 2006
Norihiko Kikuchi, Nagano, JP;
Yoshinori Nonaka, Nagano, JP;
Kazuya Tatani, Nagano, JP;
Masahiro Hiratochi, Nagano, JP;
Yu Kuramochi, Nagano, JP;
Masayuki Isaji, Nagano, JP;
Kazuo Shimizu, Nagano, JP;
Takashi Miyagi, Nagano, JP;
Norihiko Kikuchi, Nagano, JP;
Yoshinori Nonaka, Nagano, JP;
Kazuya Tatani, Nagano, JP;
Masahiro Hiratochi, Nagano, JP;
Yu Kuramochi, Nagano, JP;
Masayuki Isaji, Nagano, JP;
Kazuo Shimizu, Nagano, JP;
Takashi Miyagi, Nagano, JP;
Kissei Pharmaceuticals, Co., Ltd., Nagano, JP;
Abstract
The present invention provides benzimidazole derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an inhibitory activity on sodium-dependent nucleoside transporter 2 and are useful for a disease associated with an abnormality of plasma uric acid level. The compounds of the present invention are useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like. In the formula, n is 1 or 2; Rand Rare H, a halogen atom, cyano group, optionally substituted alkyl group, optionally substituted aryl group or the like; Ris H, a halogen atom, optionally substituted alkyl group or the like; Rand Rare H, a halogen atom, OH or the like; and Rand Rare H or OH: Ris F or OH.