The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2009
Filed:
Mar. 24, 2004
Joseph S. M. Peiris, Hong Kong, CN;
Kwok Yung Yuen, Hong Kong, CN;
Lit Man Poon, Hong Kong, CN;
Yi Guan, Hong Kong, CN;
Kwok Hung Chan, Hong Kong, CN;
John M. Nicholls, Hong Kong, CN;
Frederick C. Leung, Hong Kong, CN;
Joseph S. M. Peiris, Hong Kong, CN;
Kwok Yung Yuen, Hong Kong, CN;
Lit Man Poon, Hong Kong, CN;
Yi Guan, Hong Kong, CN;
Kwok Hung Chan, Hong Kong, CN;
John M. Nicholls, Hong Kong, CN;
Frederick C. Leung, Hong Kong, CN;
The University of Hong Kong, Hong Kong, CN;
Abstract
The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans ('hSARS virus'). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated(SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.