The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Oct. 20, 2003
George Janini, Rockville, MD (US);
Haleem J Issaq, Frederick, MD (US);
Timothy D Veenstra, Jefferson, MD (US);
Thomas P Conrads, Frederick, MD (US);
Kenneth L Wilkens, Nashville, TN (US);
George Janini, Rockville, MD (US);
Haleem J Issaq, Frederick, MD (US);
Timothy D Veenstra, Jefferson, MD (US);
Thomas P Conrads, Frederick, MD (US);
Kenneth L Wilkens, Nashville, TN (US);
Abstract
Contiguous capillaries useful for separating and electrospraying a fluid comprising analyte and electrolyte are provided. The contiguous capillaries have spray tips at one end of the capillaries and electrically conductive portions in proximity to the spray tips. Methods for making the contiguous capillaries and their use as electrospray sources are also disclosed. Apparatus and methods for conveying analyte ions from the capillaries into analytical instruments, such as a mass spectrometer, are also disclosed. The disclosed contiguous capillaries may be used to carryout electrophoresis separation and electrospray ionization of analytes. Methods for obtaining the mass spectra of macromolecular analytes at concentrations lower than previously possibly are provided using the apparatus and procedures described herein.