The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Aug. 19, 2004
Tak-hang Chan, Hong Kong, CN;
Wai-har Lam, Hong Kong, CN;
Larry Ming-cheung Chow, Hong Kong, CN;
Qing Ping Dou, Detroit, MI (US);
Deborah Joyce Kuhn, Detroit, MI (US);
Aslamuzzaman Kazi, Detroit, MI (US);
Tak-Hang Chan, Hong Kong, CN;
Wai-Har Lam, Hong Kong, CN;
Larry Ming-Cheung Chow, Hong Kong, CN;
Qing Ping Dou, Detroit, MI (US);
Deborah Joyce Kuhn, Detroit, MI (US);
Aslamuzzaman Kazi, Detroit, MI (US);
The Hong Kong Polytechnic University, Hong Kong Sar, CN;
Wayne State University, Detroit, MI (US);
University of South Florida, Tampa, FL (US);
McGill University, Montreal, Quebec, CA;
Abstract
(−)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (−)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formula 10, wherein Ris selected from the group of —H and Cto Cacyl group; R, R, and Rare each independently selected from the group of —H, —OH, and Cto Cacyloxyl group; and at least one of R, R, or Ris —H. The derivatives of (−)-EGCG that is at least as potent as (−)-EGCG. The carboxylate protected forms of (−)-EGCG and its derivatives are found to be more stable than the unprotected forms, which can be used as proteasome inhibitors to reduce tumor cell growth.