The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Mar. 06, 2006
Shuji Takashi, Nagano, JP;
Indu Parikh, Chapel Hill, NC (US);
Kenneth B. Adler, Raleigh, NC (US);
Linda D. Martin, Apex, NC (US);
Yuehua LI, Pearland, TX (US);
Shuji Takashi, Nagano, JP;
Indu Parikh, Chapel Hill, NC (US);
Kenneth B. Adler, Raleigh, NC (US);
Linda D. Martin, Apex, NC (US);
Yuehua Li, Pearland, TX (US);
Biomarck Pharmaceuticals, Ltd., Raleigh, NC (US);
Abstract
The present invention includes methods of modulating cellular secretory processes. More specifically the present invention relates to modulating or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from the vesicles or granules in the inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. MANS peptide and active fragments thereof are useful in such methods.