The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Apr. 25, 2008
Applicant:
Antoni Kozlowski, Huntsville, AL (US);
Inventor:
Antoni Kozlowski, Huntsville, AL (US);
Assignee:
Nektar Therapeutics AL, Corporation, Huntsville, AL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08F 16/06 (2006.01); C08F 116/06 (2006.01); C07D 249/08 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an organic solvent. The polymer backbone can be poly(ethylene glycol). The 1-benzotriazolylcarbonate ester can then be reacted directly with a biologically active agent to form a biologically active polymer conjugate or reacted with an amino acid, such as lysine, to form an amino acid derivative.